Effect Of Selenium On Stress Oxidative In ASD Children


  • Neny Triana , Mohammad Sulchan , Maria Maxitalia , Maria Suryani




Background: Oxidative stress in autism spectrum disorder (ASD) children causes developmental disorders in ASD children. Administration of selenium to a mouse model of ASD can reduce oxidative stress. Studies on the effects of selenium on oxidative stress in ASD children is still limited. This study aims to evaluate the effect of selenium administration on oxidative stress in ASD children

Methods and Results: Randomized controlled trial study conducted in children with ASD. The study divided the participants into 3 groups with random allocation, namely the selenium I intervention group (n=22), the selenium 2 intervention group (n=22) and the control group (n=21). Selenium is given in the form of supplements and functional foods for 12 weeks. Oxidative stress was assessed by examining glutathione peroxidase (GPx) levels. Wilcoxon test, Kruskal-Wallis test, and Man-Whitney U test used in this study.

Results: The mean changes in GPX levels after intervention in the intervention group 1, intervention group 2, and the control group were 5.08, 5.79, and 9.73, respectively. There was no significantly difference in changes in GPX levels after administration of selenium.

Conclusion: Selenium could not decrease oxidative stress significantly in ASD children.



2023-01-01 — Updated on 2023-01-01




How to Cite

Effect Of Selenium On Stress Oxidative In ASD Children. (2023). Journal of Pharmaceutical Negative Results, 389-392. https://doi.org/10.47750/pnr.2023.14.S01.43