The Role Of Platelet Indices In Ischemic Heart Disease

Abstract

Introduction: Ischemic heart disease  is one of the leading cause for death worldwide.platelet plays an important role in the pathogenesis of  acute coronary syndrome.platelet indices can be detected earlier,inexpensive,widely available and easily recordable inmost clinical laboratories,so it is one of the potential marker inischemic heart disease patients.the main objective of this study is to determine the correlation between platelet indices with  the spectrum of Ischemic Heart Disease.

Materials and methods: This is a prospective hospital-based study was carried on 50 patients over one year. The patients were divided into two groups GROUP A (Case Group): diagnosed and admitted with  ischemic heart disease GROUP B (Control Group): patients with non-cardiac chest pain.platelet indices which include platelet count, Mean platelet volume and platelet distribution width were determined in all groups compared and statistically analysed.

Results: Platelet count is significantly low in case group (101.52± 79.90) compare with control group (222.44±82.67). PDW are significantly high in case group (15.80± 5.17) compare with control group (12.04± 2.12). MPV are also significantly high in case group (11.69±2.52) compare with control group (10.23±1.01).

Conclusion: The platelet volume indices are an important, simple, effortless and a cost-effective tool, generated as a by-product of automated blood counts, useful in predicting the development of an acute coronary event sometimes in the near future and therapeutic modification for improved patient's cardiovascular care.