A Convenient Routes For Synthesis Of New Series Of Spiro Five Heterocyclic Compounds Derived From Thiazoloquinazolinone

Abstract

Dimedone, 2-amino thiazole and substituted benzaldehyde have been reacted through Biginelli reaction as a type of multicomponent reaction and accelerated by microwave irradiation in power (450 watt) in acidic media from boric acid to afford 8,8-dimethyl-5-aryl-8,9-dihydro thiazolo[3,2-a]quinazolin-6-one (B₁-₆), these carbonyl compounds were later used as active synthon to prepare a new series of Schiff bases represented by compounds 8,8-dimethyl-5-aryl-8,9-dihydro thiazolo[3,2-a]quinazolin-6-thiocarbohydrazone (C₁-₆) by its reaction with thiocarbohydrazide which in turn underwent intracyclization reaction with acetic anhydride to afford the titled  compounds 8,8-dimethyl-5-aryl-8,9-dihydro thiazolo[3,2-a]quinazolin-6-spiro(3-acetyl-5-acetohydrazide)-1,3,4-triazoline (D₁-₆)