Recent Progress, Therapeutic Concepts And Pharmaceutical Challenges Of Dendrimer Based Drug Delivery System

Abstract

Nanoscale size, a multi-functionalized surface, high branching, a cavernous interior, and other distinctive structural features of dendrimers make them perfect drug delivery systems. In the past forty years, dendrimer research has expanded tremendously from synthesis to use since Fritz Vögtle originally published the first dendrimer in 1978. Nanoscale size, a multi-functionalized surface, high branching, a cavernous interior, and other distinctive structural features of dendrimers make them perfect drug delivery systems. This review focuses on the most recent advancements in the use of dendrimers as drug and gene carriers, including active drug release strategies to release the drug or gene from the dendrimer in response to stimuli, size-adaptive and charge-reversal dendrimer delivery systems that can better utilise the size and surface characteristics of dendrimer bulk and micro/nano dendrimer gel delivery systems, and other recent developments. Recent developments in dendrimer formulations may result in the creation of novel gene and drug products as well as combination medicines.