FORMULATION AND EVALUATION OF NEOMYCIN SULFATE HYDROGELS FOR WOUND HEALING

Abstract

Purpose: The present study was designed to study the Neomycin Sulfate (NS)-loaded hydrogels to heal wounds.
Material and Method: NS-loaded hydrogels were prepared by simple stirring method.
Results: The prepared formulation exhibited good consistency, homogeneity and gelling strength. The application of gel on healthy volunteers revealed gels to be safe for skin. It also exhibited pH between 7.4-8.0 and drug content between 100±4% evaluated through microbial assay. In-vitro drug release data showed a fast initial drug release during the first 1 h, followed by a slower and sustained release over 5 h.
Conclusion: The finding suggests that NS based hydrogel is suitable for drug delivery through topical application to enhance the dermal contact time and improved patient compliance.