Gelatin Adsorbed Solid Lipid Nanoparticles (SLN) For Targeted Drug Delivery Of Anti -Inflammatory Drug

Abstract

The purpose of this research was to study the effects of surface modified solid lipid nanoparticle of diclofenac as targeted and controlled drug delivery system. Diclofenac SLN were developed using glyceryl monostearate by solvent emulsification diffusion technique followed by sonication and then characterized by particle size analysis, zeta potential, TEM, drug entrapment efficiency. The in vitro dissolution profile showed that the GSLN were able to sustain the release of the Diclofenac for considerable period of time (89.04% within 24 hr.). The in vitro data fits to zero order, first order, Higuchi model, r² value showed the drug release characteristics and mechanism. The paw edema test after i.p administration showed that GSLN had extended anti-inflammatory effects compared with Diclofenac. The stability study showed the no alteration in physical appearance, size, shape, drug content and in-vitro drug release after storage at 4⁰C and 25⁰C during the 60 day (7, 15, 30, 45, and 60 days). These results suggest that GSLN could be promising target drug delivery for Diclofenac with an extended pharmacological effect owing to delayed released of parent drug and were stable at room temperature.