QUERCETIN LOADED MAGNETITE NANOPARTICLES FOR METASTATIC BREAST CANCER

Abstract

Breast cancer is the most prevalence cancers in women and 1.67 million new cases of breast cancer were diagnosed. Quercetin is an active antioxidant flavonoid that can protect low-density lipoproteins from free radicals and it also possess pro-oxidant activity which could be used to treat metastatic breast cancer. In this work, we have formulated the magnetite nanoparticles loaded with quercetin for metastatic breast cancer with help of arbitrary interface of DOE for optimization.  The developed MNP formulation's physiochemical characterization was found to be sufficient. The in vitro drug release study showed an initial release (48.55±2.09%) within 90 minutes, followed by a sustained drug release (99.35±4.58 %) profile at the end of 87^th hours and the kinetics of the in vitro release was calculated. The in vitro compatibility with MCF-7 cells showed that the quercetin loaded MNP was compatible and IC50 value 32µg/ml. These findings suggest that the quercetin loaded MNP has anticancer potential against metastatic breast cancer and they may be explored further for their effect through in vivo studies.