“To Study The Association Of Leptin As A Predictive Marker In Obese And Non-Obese Women With Polycystic Ovary Syndrome Patients.”

Abstract

Background: Polycystic ovary syndrome(PCOS) is a common endocrine problem where Leptin, an adipocyte‑derived hormone encoded by ‘ob’ gene, has been proposed as the peripheral signal indicating the adequacy of nutritional status for reproductive functions.

Circulating leptin correlates strongly with obesity, which is frequently associated with polycystic ovarian syndrome (PCOS). However, the changes in serum leptin levels in patients with PCOS and its predictive value for PCOS remain obscure. We intend to analyze the association of serum Leptin levels as a predictive marker in obese and non-obese women with Polycystic Ovary Syndrome Patients.

Material and Methods: The study comprised of 85 patients with PCOS and 75 controls without PCOS.Each group was analysed for the following parameters as TSH, Prolactin, FSH, LH,AMH, Totalcholesterol,Systolic/diastolic(BP),BMI,Leptin,MDA(Malondialdehyde) and SOD( Superoxide dismutase).The validity of leptin toward the diagnosis of PCOS or leptin combined with these parameters was estimated by Descriptive and inferential statistical analysis at 5% level of significant.

Results: The results of the present study indicated that an increased level of leptin among women with PCOS positively associated with FSH, LH, TSH, Total cholesterol, MDA in PCOSpatients. However, there was no statistical significant correlation between Insulin and the Body Mass index.

Conclusion: Higher leptin levels were independently associated with the risk of PCOS. However, there was no significant correlation between insulin and BMI. Elevated leptin levels may contribute to etiology of PCOS but further, well-designed prospective studies are still needed to elucidate the precise association between leptin and PCOS.