Synthesis, Characterization, and Molecular Docking of New Tetrazole Derivatives as Promising Anticancer Agents

Authors

  • Yuosra Khalaf Alasadi Department of Chemistry, College of Education for Pure Science, Tikrit University, Tikrit,42, Iraq
  • Fawzi Hameed Jumaa Department of Chemistry, College of Education for Women, Tikrit University, Tikrit, 42, Iraq
  • Adil Hussein Dalaf Department of Chemistry, College of Science, Tikrit University, Tikrit, 42, Iraq
  • Safa Mahmood Shawkat Department of Chemistry, College of Education for Women, Tikrit University, Tikrit, 42, Iraq
  • Mohammed Ghanam Mukhlif Department of Chemistry, College of Science, Tikrit University, Tikrit, 42, Iraq

DOI:

https://doi.org/10.47750/pnr.2022.13.03.079

Keywords:

Anticancer, Dapsone Reaction, Diazotisation, Tetrazole

Abstract

This work included the synthesis of azo dye [F1] by the reaction of dapsone's diazonium salt with salicylaldehyde at (0-5) 0C, synthesis of Schiff base [F2-F4] through the reaction of the substituted aromatic amine with aldehyde group in azo compound [F1] in ethanol, synthesis of tetrazole derivatives [F5-F7] by reaction of Schiff base with sodium azide in THF, and characterization of the synthesized compounds by using spectroscopic techniques FT-IR, 1H-NMR using DMSO-d6 as a solvent, SEM, in addition, melting point. This work also included a study of anticancer activity for some prepared compounds [F3, F7]. Besides, Molecular docking of the prepared compounds with the cancer proteins has also been studied using the Auto Dock v4.2 program in an attempt to find out the inhibitory potential of the compounds and the places of these compounds with the active site of the protein and compare them with the practical results obtained.

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Published

2022-09-21

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Section

Articles

How to Cite

Synthesis, Characterization, and Molecular Docking of New Tetrazole Derivatives as Promising Anticancer Agents. (2022). Journal of Pharmaceutical Negative Results, 13(3), 513-522. https://doi.org/10.47750/pnr.2022.13.03.079