In Vivo Evaluation Of The Antidiabetic Activity Of 2-Azetidinone Derivatives Induced By Streptozotocin In Rats

Abstract

This experimental study includes the synthesis of a novel N- Substituted-1, 3, 4-oxadiazol-2-yl)-3-chloro-4-phenylazetidin-2-one by refluxing substituted (styryl)-N-benzylidene-1, 3, 4-oxadiazol-2-amine in C₂H₅OH. The objective of this research was to evaluate the antidiabetic action of 2-azetidinonederivatives in STZ-induced diabetic rats. Azetidinone derivatives (AD1-AD5) were evaluated for antidiabetic action in STZ-induced diabetes in rats (50mg/kg, orally) was administered every day for twenty-one days in STZ induced diabetic rats. The result shows that compounds AD1 and AD5 are having significant antidiabetic activity, furthermore these compounds significantly lower Blood Sugar levels (BSL) and obesity in rats.