Cognitive Enhancing And Antioxidant Activity Of Ethyl Acetate Soluble Fraction Of The Methanol Extract Of Pisonia Alba Leaves In Scopolamine-Induced Amnesia

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  • N Sriram , Susmitha Uppugalla , Kavitha Rajesh , S. Someshwara n , B Senthil Kumar , Prasad P Nadedkar , Shanta K Adiki

DOI:

https://doi.org/10.47750/pnr.2022.13.S09.460

Abstract

Evaluation of Pisonia alba's cognitive-improving and antioxidant activity was the goal of the current investigation. In mice, scopolamine (1 mg/kg, i.p.) administration decreased learning and memory, which is related to altered brain oxidative status. To evaluate cognitively enhancing activity, the object recognition test (ORT) and passive avoidance test (PAT) were used. The methanol extract of P. alba was administered to the animals at doses of 25, 50, and 100 mg/kg, p.o. The methanol extract of P. alba's ethyl acetate soluble fraction (EASF) reduced amnesia brought on by scopolamine and age. The older and scopolamine group in ORT showed a considerably lower discrimination index (DI). EASF pretreatment greatly raised the DI. Mice given scopolamine had considerably lower step-down latencies in PAT (SDL). EASF therapy resulted in a notable rise in SDL in all animal groups, including young, old, and scopolamine-treated animals. Scopolamine therapy enhanced lipid peroxidation and lowered levels of superoxide dismutase (SOD) and glutathione reductase, according to the biochemical study of the brain (GSH). By drastically reducing LPO and reversing the decline in brain SOD and GSH levels, extract was administered. P. alba treatment enhanced memory in amnesic mice and reduced the oxidative stress brought on by scopolamine. Increased cellular antioxidants may be the cause of P. alba's protective mechanism. The findings of the current investigation indicated that P. alba may be useful in the treatment of cognitive disorders because it may have a protective effect against scopolamine-and age-induced forgetfulness.

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Published

2022-12-01 — Updated on 2022-12-01

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Cognitive Enhancing And Antioxidant Activity Of Ethyl Acetate Soluble Fraction Of The Methanol Extract Of Pisonia Alba Leaves In Scopolamine-Induced Amnesia. (2022). Journal of Pharmaceutical Negative Results, 3740-3749. https://doi.org/10.47750/pnr.2022.13.S09.460