DESIGN AND FORMULATION OF NOVEL COLON TARGETED FENOPROFEN TABLET

Abstract

Fenoprofen is a propionic acid derivative and is a protypical NSAID used to reduce fever, mild to moderate pain, inflammatory diseases like rheumatoid, juvenile arthritis and ankylosing spondylitis, Fenoprofen Plasma half-life is approximately 3 hours, and having rapid absorption which requires frequent dose administration, So to avoid repeated frequent dose administration The colon targeted tablets of Fenoprofen tablets were prepared by direct compression method by using natural polymers like xanthan gum and guar gum, alone and in combinations in different concentrations. In the present work, total nine formulations were prepared and the detailed composition is shown in Table. The prepared colon targeted tablets of Fenoprofen were then subjected to FTIR, pre compression parameters like Angle of repose, Bulk density, Tapped density, Carr’s index and Hausner’s ratio. Then the tablets were evaluated for post compression parameters like Thickness, Hardness, average weight, friability, drug content, in vitro dissolution, and drug release kinetics. Among all the nine formulations formulated by using xanthan gum and guar gum. Formulation F7 containing xanthan gum and guar gum in 1:1 ratio shows sustained drug release by targeting the drug release at colon pH. when compared with all other formulations. So the drug release kinetics were performed for the F7 formulation containing xanthan gum and guar gum in 1:1 ratio. The diffusion exponent ‘n’ values of Korsemeyer-Peppas model was found to be in the range of 2.359 for the Fenoprofen colon targeted tablets prepared with xanthan gum and guar gum in 1:1 ratio indicating super case transport of drug through Fenoprofen colon targeted tablets.