Antibacterial Effectivity of Silver Nanoparticles Biosynthesized from Oral Pathogenic Staphylococcus aureus Isolate Against Other Gram Positive Isolates

Authors

  • Jassim Fatehi Ali
  • Ibrahim Hasan Yaseen
  • Semaa F. H. AL-Abedi
  • Bushra Habeeb Ahmed
  • Younis Saadi Saed

DOI:

https://doi.org/10.47750/pnr.2022.13.03.041

Abstract

In recent years, staphylococcal infections, caused mostly by multiple-drug-resistant strains, have become particularly prevalent in clinical settings. Due to the development of antimicrobial drugs, the breakout and resistance of infectious diseases caused by resistant Staph aureus, pharmaceutical companies and researchers are now researching and developing novel unconventional antimicrobials. In this field, nanotechnology illustrates an innovative and unequaled strategy for developing novel metallic nanoparticle-based architectures with potential antibacterial properties.. In this study, cell extract of MRSA strain was used for combination of silver nanoparticles. The synthesized MRSA-AgNPs were identified and described utilizing UV-visible spectroscopy, XRD, and SEM. Their antibacterial potential was evaluated on MRSA and MSSA strains which have been genotypically diagnosed through the disclosure of 533 base per mecA gene. The minimal inhibitory concentration (MIC) using micro dilution assay, and minimal bactericidal concentration (MBC) of Ag-NPs across methicillin sensitive Staph. aureus (MSSA), and methicillin resistant Staph. aureus (MRSA) were inspected in this investigation. Our outcomes indicated that MIC & MBC values of Ag-NPs to MRSA was 7.8 μg/ml and 31.3 μg/ml, separately, whilst MIC & MBC values toward MSSA were 3.9 μg/ml & 15.6 μg/ml, separately. The accomplished outcomes proposed that Ag-NPs display great effect against two significant clinical tested isolates in any case of their drug resistant developing mechanisms

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Published

2022-09-20

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Articles

How to Cite

Antibacterial Effectivity of Silver Nanoparticles Biosynthesized from Oral Pathogenic Staphylococcus aureus Isolate Against Other Gram Positive Isolates. (2022). Journal of Pharmaceutical Negative Results, 13(3), 255-262. https://doi.org/10.47750/pnr.2022.13.03.041