Electrochemical sensing of Metoprolol using MIP/TiO2 based carbon paste electrode

Abstract

Metoprolol tartrate is beta blocker prescribed for the treatment of hypertension, angina pectoris and cardiac arrhythmias. The electrochemical oxidation of Metoprolol was checked at different modified carbon paste electrodes in phosphate buffer solution (pH =7) using cyclic voltammetry (CV), Differential pulse voltammetry (DPV) and electrochemical impedance spectroscopy (EIS). CV shows an irreversible oxidation peak between the potential range of 0.4 to 1.8V in the phosphate buffer solution at TiO2/MIP/CPE. The Nyquist plot of TiO2/MIP/CPE gives less charge transfer resistance (Rct) as compared to MIP/CPE due to an increase in the conductivity of the surface because of TiO2 particles. The modified electrode gives trouble-free electron transfer due to the porous nature of the material. The fabricated sensor selectively determines Metoprolol amperometrically in the pharmaceutical sample.