Study Of Specular Microscopic Findings Of Cornea In Patients With Type2 Diabetes Mellitus – A Hospital Based Study


  • Dr. Lavanya.S , Dr. C.Indhu , Dr. K.Namitha Bhuvaneswari



Background: Corneal evaluation is an important tool in Ophthalmologists daily practice. Hyperglycemia is a metabolic condition that can have damaging effects on almost all body tissues. Ophthalmic complications of hyperglycemia are most notable in the cornea and the retina. Retinal impairment is responsible for the majority of visual impairments in diabetics; however, corneal impairment remains a major vision-hindering pathology. Diabetes mellitus has a significant effect on all layers of corneal. This study is carried out to compare the morphological characteristics of corneal endothelium in type 2 diabetic patients and age-matched healthy subjects by specular microscopy.

Objective: The aim of this study is to compare the corneal endothelial cell density, morphological features, and central corneal thickness in type 2 diabetes mellitus with age-matched, nondiabetic control subjects using noncontact Specular Microscope.

Methodology: A Hospital based, Cross Sectional Study. This includes 50 patients with type 2 DM and 50 control (nondiabetic) subjects. All participants will undergo a complete ophthalmological examination. Corneal endothelial measurements were performed using a noncontact specular microscopy and the findings of all patients will be compared. Data will be analysed using MS Exel - SPSS SOFTWARE version 2.2

Results: Among the 100 study participants 50 were diabetic and 50 were non-diabetic. The mean age among diabetic were 59.60±7.9 and the mean age among non-diabetic study participants were 57.72±6.3. The morphological changes of corneal endothelium is measured by spectral microscopy and found that the that ECD was significantly lower (2646.52 ± 349.63 vs. 2678.67± 351.76 cells/m2; p = 0.02).The central cornea was thicker in diabetic group compared to non-diabetic group (61.80 ± 33.10 vs. 542.73 ± 34.20; p = 0.00). In diabetic patients the coefficient of variance was significantly increased than non-diabetic group. There is also significant change in percentage of hexagonal cells within both the groups.

Conclusion: Keratopathy is an important complication, in that respect we can suggest it should be evaluated more cautiously in diabetic patients



2022-11-18 — Updated on 2022-11-18





How to Cite

Study Of Specular Microscopic Findings Of Cornea In Patients With Type2 Diabetes Mellitus – A Hospital Based Study. (2022). Journal of Pharmaceutical Negative Results, 2107-2111.