Evaluation Of Hepatoprotective Effect Of Dietary Inclusion Of Ficus Glomerata Fruits Against Cisplatin-Induced Hepatic Damage In Rats

Abstract

In the present study, cisplatin-induced liver impairment was evidenced by an increase in serum ALT, ALP, and AST and hepatocyte
cell degeneration, inflammatory infiltrate, and necrosis. These changes persisted on the 6th day due to a single dose of 6 mg/kg cisplatin.
The 2% and 4% of Ficus glomerata normalized serum ALT, ALP, AST, LOD, GSH, SOD, and catalase of the liver. The researchers
reported that cisplatin administration induced a significant increase in serum ALT, AST, and ALP and a significant decrease in serum
total bilirubin, total protein, and albumin levels. The ability of cisplatin to cause alterations in the activity of these enzymes could be a
secondary event following Cisplatin-induced liver damage with the consequent leakage from hepatocytes. The present study revealed
that significantly decreased levels of ALT, ALP, and AST in blood serum due to their antioxidant effects and their ability to act as free
radical scavengers, thereby protecting membrane permeability after treatment with 2% and 4% of Ficus glomerata indicate
hepatoprotective and curative effects.
Actually, cisplatin contributed to various mechanisms of liver dysfunction consisting of cellular toxicity, vasoconstriction in the renal
microvasculature, and proinflammatory effects, by producing free radical oxidative stress, which participated in the decline of
antioxidant enzymes in the liver and led to liver injury. Hence, the possible mechanism of hepatoprotection and curative effect of
Ficus glomerata supplement could be due to its good antioxidant potential content; it might contribute to free radical scavenging and
antagonistic hepatotoxicity that were produced by cisplatin in liver injury.