Prognostic Use Of Fasting Lipid Profile, Erythrocyte Sedimentation Rate And C - Reactive Protein In The Management Of Hypertensive Individuals With Chronic Kidney Disease

Abstract

Introduction: One major cause of secondary hypertension is chronic kidney disease and this has broadly triggered a vast majority of
cardiovascular events. With growing evidences of atherogenic dyslipidamia in CKD patients. The present study assessed the fasting
lipid profile, erythrocyte sedimentation rate and C-reactive protein level in adult hypertensive with chronic kidney disease at Nnamdi
Azikiwe University teaching hospital, Nnewi, and relates the findings to the prevalence of cardiovascular disease.
Methods: The study conveniently selected 80 hypertensive individuals (female =45; male = 35) with evidence of CKD from internal
medicine clinic and 80 (female =40; m = 40) non hypertensive individuals without CKD (control) within the ages of 20-70 years.
Fasting lipid profile [total cholesterol (TC), low density lipoprotein (LDL), high density lipoprotein (HDL), triglyceride (TG)] and
CRP were determined using enzymatic method while ESR was done using the Westergren method
Results: The result shows that serum TC, LDL and TG were significantly (P=.000) increased while, HDL was decreased in
hypertensive individuals with CKD when compared with non-hypertensive individuals without CKD (P=.017). CRP and ESR were
significantly (P=.000) increased in hypertensive individuals with CKD compared with their non-hypertensive counterpart.
Conclusions: This suggests the role of abnormal lipid metabolism and inflammation in renal dysfunction. With this finding, high level
of lipoprotein with increased Hs- CRP and ESR can be used as indices for early diagnosis and management of hypertensive
individuals to reduce some of the risk factors that may predispose them to CKD and further cardiovascular complications.