Comparative Evaluation of Anti-Arthritic Activity of Pongamia Pinnata, Bryophyllum Pinnata and Their Combined Formulation in Fca Induced Arthritis Rat Model

Abstract

The present study deals that the in-vivo comparative evaluation of anti-arthritic activity of Pongamia pinnata seeds, Bryophyllum
pinnata leaves and their combined formulation using Dexamethasone as a standard. Rheumatoid arthritis (RA) is the most common
inflammatory arthritis and affects the connective tissues throughout the body, but especially around the joints. Pongamia pinnata and
Bryophyllum pinnatum have several uses which ascribed in traditional medicine. Pongamia pinnata used in diabetes, Epilepsy,
hypertension, skin ailments and rheumatic arthritis. Bryophyllum pinnatum used in inflammatory disease, analgesic, ulcer, kidney and
gall bladder stones. In vivo method, the antiarthritic effect of Pongamia pinnata seed and Bryophyllum pinnata leave combined
extract (PBCE) was confirmed by Freund’s complete adjuvant (FCA) arthritis induced rat. FCA consists of inactivated dried
mycobacterium which stimulates effectively cell mediated immunity and produce immunoglobulin. In the present study, the results
show that the Pongamia pinnata ethanolic extract (PPEE), Bryophyllum Pinnatum ethanolic extract (BPEE) and Pongamia
Bryophyllum combined extract (PBCE) had significantly anti-arthritic effect on behaviors, hematological and biochemical parameters.
Both plants are rich in antioxidant, flavonoids and polyphenols which are inhibit lipid. Treatment with PBCE reduces the all
biochemical serum parameters similar as dexamethsone. The present investigation showed that PBCE (500mg/kg) was observed
highly significant reduces paw swelling, hematological parameters and biochemical parameters in the FCA induced arthritis rats.