DISSOLUTION RATE ENHANCEMENT AND PHYSICOCHEMICAL CHARACTERIZATION OF RIVAROXABAN SOLID DISPERSIONS WITH POLOXAMER 188

Abstract

The aim of the work was to enhance the dissolution rate of rivaroxaban by preparing its solid dispersions (SDs) using hydrophilic carrier poloxamer 188. The prepared solid dispersions were characterized by Fourier-transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). Both solubility and dissolution rate of the drug in these formulations were increased. The SDs of rivaroxaban with poloxamer 188 were prepared at 1:1, 1:2 and 1:3 w/w ratios by physical mixing, melting and solvent evaporation techniques. The used hydrophilic carrier showed more than two fold increase in dissolution rate in their prepared solid dispersions by melting or solvent evaporation techniques. The FTIR spectroscopic and DCS thermal studies showed the compatibility of rivaroxaban and absence of well-defined drug polymer interactions, though shift in peaks observed due to formation of new bonds.