Study Inhibitory Effects Of Lactobacillus Plantarum Against Staphylococcus Aureus Methicillin Resistance

Abstract

The current study aimed to study effects of  Lactobacillus plantarum on Staphylococcus aureus that isolated from different clinical sources(burns, wounds, urine) . The results showed the distribution rates of isolates for the sources from which bacteria were isolated. The highest percentage of burns sources was 85.7%, followed by wounds sources 83.3% and urine 60%.These isolates of S. aureus showed 100% resistance against Vancomycin, 90% against Tetracycline and Methicillin, 85% and 83% to Penicillin and Erythromycin, respectively, and 80% for both Ciprofloxacin and Oxacillin, the resistance was 75% and 74% to Novobiocin and Levofloxacin, respectively, while the rest of the antibiotics Trimethoprim / Sulfa Methoxamine recorded 51%, and Rifampicin and Ofloxacin had a resistance ratio of 38% and 5%, respectively. It was observed in this study the Lactobacillus plantarum broth culture  appeared inhibitory activity against isolates of Staphylococcus. While the supernatant  did not give inhibitory activity except for the isolate of Staph3.Also,it was observed that the biofilm of all methicillin-resistant S. aureus isolates using Lactobacillus plantarum broth showed significant differences compared to control. In addition, the scanning electron microscope results showed a decrease in the thickness of the biofilm after treatment with L. plantarum