The Effect Of Recombinant FSH Treatment On Ceruloplasmin Activity In Infertility Women Undergoing IVF/ICSI

Abstract

Infertility can be resulted by an underlying medical problem that damages the fallopian tubes, effects with ovulation, or cause hormonal complications. One of the most effective treatments of this disorder is the IVF/ICSI reproductive technique which can be considered as a first-stage treatment strategy for women over age (<48) years. The aim of this study to estimate some antioxidant levels in IVF undergoing recombinant FSH (rFSH) treatment. During infertility treatment by ovarian stimulation, gonadotropins are used to ripen follicles and induce ovulation, Female infertility was induced in the subjects (n=32) and healthy women (n=30), all women were undergoing IVF/ICSI, and all samples collected from the Iraqi Specialty Center for IVF. Ceruloplasmin Total ferroxidase (activity and specific activity), ceruloplasmin concentration, ceruloplasmin oxidase (activity and specific activity), and level of copper were measured in all participants before and after recombinant FSH therapy. rFSH therapy was included to be associated with a significant decreased (P<0.05) ceruloplasmin Concentration, Ceruloplasmin oxidase specific activity, and significant increase (p<0.05) of ceruloplasmin total ferroxidase activity, but show no-significant differences (P>0.05) with Ceruloplasmin oxidase activity, and Copper concentration whereas showed no-significant difference (p>0.05) with ceruloplasmin ferroxidase specific activity.