THE EFFECT OF GIVING PLANTAIN PEEL EXTRACT (Musa paradisiaca) ON MALONDIALDEHYDE LEVELS IN WISTAR RATS EXPOSED TO FILTER CIGARETTE SMOKE

Abstract

Background: Free radicals from filter cigarettes can contribute to the body's oxidative stress. Malondialdehyde is a substance that the body produces in response to oxidative stress. Antioxidants found in plantain peel extract can be used to counteract oxidative damage.
Aim: This study sought to determine whether Wistar rats exposed to filtered cigarette smoke could have their MDA levels reduced by a plantain peel extract.
Methods: On Wistar rats, this study used an actual experimental design with a post-test-only control group. Twenty-eight rats from the research sample were split into 4 separate groups. K+ received exposure to cigarette smoke, P1 received exposure to cigarette smoke and extracted at a dose of 200mg/kg BW, and P2 received exposure to cigarette smoke and extracted at a dose of 400mg/kg BW. K- serves as the negative control. K+ received exposure to cigarette smoke. The retroorbital plexus vein was used to draw blood from the dead rats afterward. MDA levels in the plasma were measured using the TBARS technique.
Results: The average output of MDA levels in the K1, K2, P1, and P2 groups was 1.695 ppm, 2.430 ppm, 1.791 ppm, and 3.115 ppm, respectively. The K- and K+ groups showed a significant difference in the Mann-Whitney test (p=0.037), as did the K+ and P1 group (p=0.010), K+ and P2 group (p=0.025), and P1 and P2 group (p=0.004).
Conclusion: MDA levels in Wistar rats exposed to filter cigarette smoke could be decreased by administering plantain peel extract.