Influence Of Eudragit RSPO And Polycaprolactone On The Release Rate And In Vitro Evaluation In The Formulation Of Sustained Release Orlistat Matrix Microparticles

Abstract

The aim of the study is to formulate Eudragit RSPO and polycaprolactone floating microparticles for enhanced gastric retention and sustained drug delivery by using solvent evaporation technique. Orlistat an anti-obese drug, was used to design gastro retentive drug delivery system. The formulated microparticles were observed for percentage recovery, swelling index, in vitro buoyancy studies and percentage drug release. The physio chemical properties of the microparticles were also studied by using drug-polymer compatibility study and found the formulation complies with the standards. In vitro drug release characteristics of the formulated microparticles were studied in simulated gastric fluid of pH 1.2 and simulated intestinal fluid of pH 7.4 respectively and found the formulation F4 containing equal amount of Eudragit RSPO and Polycaprolactone released the drug in a sustained manner in both pH conditions of 1.2 and 7.4. Floating microparticles of Orlistat were successfully prepared and it can be concluded that the formulated floating microparticles of orlistat can be used for sustained action in the stomach to improve the absorption.