Detection Of Proapoptosis Bax- Protein In Aborted Women Infected With Toxoplasma Gondii In Wasit Province, Iraq

Abstract

The current study aimed to determine the relationship between Toxoplasma gondii infection and the levels of proapoptosis Bax-protein in aborted women and normal delivery women, in Wasit province. The study included Two groups of women included patients group (300aborted women) and control group (50 non-infected normal delivery women), Serum samples from patients and control were collected and examined Anti- T. gondii (IgM, IgG and mixed infection IgM and IgG) antibodies by using cobas e411 technique then detected the levels of proapoptosis Bax- protein by using ELISA technique. The results show the percentage of Anti- T. gondii (IgM, IgG and mixed infection IgM and IgG) antibodies were 300/300 (11%,32% and 5.66%), respectively in patient, whereas 50/50no seropositive sera in control, there is high significant difference between patients and control women. The results also showed the total rate of proapoptosis Bax- protein was 146/300 (7.94±1.29) in T. gondii seropositive patients serum samples, whereas 50/50 (1.65± 0.57) in control serum samples by using ELISA, statistical analysis results indicated high significant differences between the prevalence of the infected patients and controlwomen.