The Effect of Ferric Citrate in Controlling Iron Deficiency Anemia and its Tolerability in a Sample of Iraqi Hemodialysis Patients: Randomized Controlled Clinical Trial

Authors

  • Reyadh Jassem

DOI:

https://doi.org/10.47750/pnr.2022.13.03.009

Abstract

Background: The iron deficiency anemia along with hyperphosphatemia are the main complications of dialysis patients. Traditional iron
supplement has been failed to correct iron deficiency anemia, therefore, the current study aimed to investigate the efficacy and tolerability of
new phosphate binder, ferric citrate, in a sample of Iraqi patients with end stage renal disease on maintenance hemodialysis.
Method: Prospective, randomized, open label, active controlled trial was conducted in one center for dialysis in Babylon governance.
Patients were randomized to receive ferric citrate with dose of 6 g/d and calcium carbonate with dose of 3 g/d for eight weeks. Hemoglobin
concentration, mean corpuscular hemoglobin concentration and count of RBCs along with iron store parameters were measured. The adherence
and gastrointestinal side effects were reported at the end of study.
Results: A total of 50 patients were completed the study. Ferric citrate group showed elevation in count of RBCs, hemoglobin concentration,
MCH-C and reduction in use of IV iron and erythropoietin as well as increased iron store which evidenced by elevation of ferritin level in the
participants. There were similar adverse effects in both groups, with good adherence seen in ferric citrate group.
Conclusion: A treatment with ferric citrate for 8 weeks was observed to effectively improve anemia in a sample of Iraqi patients with end
stage renal disease on maintenance hemodialysis. In addition, the use of intravenous iron and erythropoietin was reduced in ferric citrate group
with well tolerability throughout the study period. Ferric citrate may be useful alternative for restoring iron level in hemodialysis patients.

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Published

2022-09-20

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Articles

How to Cite

The Effect of Ferric Citrate in Controlling Iron Deficiency Anemia and its Tolerability in a Sample of Iraqi Hemodialysis Patients: Randomized Controlled Clinical Trial. (2022). Journal of Pharmaceutical Negative Results, 13(3), 52-65. https://doi.org/10.47750/pnr.2022.13.03.009