Clinical Interaction Effect of Azithromycin and Citalopram in New 2-[2- - (4,5-Di Methoxy Carboxy Phenyl) Azo]-Imidazole (DMCPAI) - Metal Complexes Against Nikethamide Induce Lethal Convulsion

Authors

  • Zahraa M. Ayad

DOI:

https://doi.org/10.47750/pnr.2022.13.03.003

Keywords:

Interaction, Nikethamide, citalopram, azithromycin, cyp450

Abstract

Objectives: The ligand of heterocyclic azo dye 2- [2-- (4,5- dimethoxy carboxy phenyl) azo]- Imidazole, (DMCPAI) was achieve by coupling
between a diazonium chloride solution of 2- amino - 4,5- dimethoxy benzoic acid with imidazole in alkaline ethanol solution.
Setting: Two complexes with Co(III), Ni(II)and Cu(II) ions were achieved and qualified using existing techniques such as Mass spectral and
1H- NMR.
Methods: Thirty male mice were randomly divided into six groups for determination of analgesic activity of new compounds. Animal
primary randomly divided into six groups for Interaction study between new Azo imidazole derivatives by using inducer drug for CYP450 as
Citalopram and inhibitors drugs for enzyme as azithromycin for 7 days given orally and efficacy of interaction to protect nikethamide lethality.
Experimental design of study listed as group one still control, group 2 given Nikethamide high dose 200 mg/kg.I.P alone for induced over
stimulation and tonic clonic convulsion, animals in group 3,4,5,6 after given 7 day orally daily citalopram and azithromycin for inducer
and inhibitor of CYP450,at eight day pretreatment ([Co(L)2].Cl) or [Cu(L)2] with dose 3mg/kg and post treatment with nikethamide group
treated with [Cu(L)2].
The results showed protective effect against convulsion of nikethamide via delay onset of action nikethamide, minimize number of convulsion
with simple partial type of seizures as compared with nikethamide reveal status epilepticus convulsion persistent, in conclusion, the present
study concluded that azithromycin potent inducer for CYP450 and has the ability to increase the activity of Cu(L)2 compound to decrease
toxicity of nikethamide.

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Published

2022-09-20

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Articles

How to Cite

Clinical Interaction Effect of Azithromycin and Citalopram in New 2-[2- - (4,5-Di Methoxy Carboxy Phenyl) Azo]-Imidazole (DMCPAI) - Metal Complexes Against Nikethamide Induce Lethal Convulsion. (2022). Journal of Pharmaceutical Negative Results, 13(3), 15-19. https://doi.org/10.47750/pnr.2022.13.03.003