pKa and Partition coefficient Determination of Montelukast sodium by Spectrophotometric and HPLC Technique
DOI:
https://doi.org/10.47750/pnr.2022.13.S01.249Keywords:
Montelukast sodium, Active pharmaceutical ingredient(API),Design of Buffers, Spectrophotometric Titration, High Performance liquid Chromatography (HPLC), dissociation constant(pKa), Partition coefficient (Log P).Abstract
The acid dissociation constant (pKa) of a pharmaceutical drug is a significant physicochemical parameter that impacts biopharmaceutical properties of drugs and other chemical characteristics. Determination of pKa and Partition coefficient of Montelukast Sodium by spectrophotometric technique and HPLC technique individually. From the measurement structure plan of dosage form and pharmaceutical examination point of view, the pKa and Partition coefficient are the most significant physicochemical properties of pharmaceutical drug which should be assessed. The pKa estimation of Montelukast Sodium was done by utilizing UV-Visible spectrophotometric strategy and Partition coefficient was evaluated utilizing HPLC technique. Experimental estimation value of pKa1 of Montelukast Sodium was found to be 3.3 and pKa2 of Montelukast Sodium was found to be 4.4. Two graphical techniques were utilized to estimate the acid dissociation constant (pKa) for Montelukast Sodium and the Partition coefficient of Montelukast Sodium by HPLC method was experimentally estimated to be 2.42.
