CIRCULATORY LEVELS OF TRACE ELEMENTS IN METABOLIC SYNDROME PATIENTS IN A TERTIARY HEALTH CENTRE OF UTTAR PRADESH

Abstract

Background: Metabolic Syndrome refers to a set of metabolic attributes that are correlated to each other. These metabolic attributes contribute to the development of cardiovascular diseases, Diabetes Mellitus Type II, etc. directly. Minerals are physiologically present in the human body at various concentrations. Metabolic syndrome being a cluster of metabolic disorders, participation of minerals is of paramount importance. This metabolic disorder might be associated with the disturbances in the metabolism of minerals viz; zinc, copper, iron, etc. Aim: The current study aimed to estimate the levels of serum Trace elements like CU, Zn and Fe among Metabolic Syndrome patients and compare with the levels in healthy controls. Methods: The study was conducted on a total 220 individuals out of whom two groups were divided. Metabolic Syndrome case group had 110 subjects between 25-55 age groups who were selected according to the ATP III guidelines under the consultation of experts in Medicine department. Estimation of trace elements viz; Serum Copper and Serum Zinc was estimated by colorimetric methodology. Serum Iron was estimated by Ferrozine mothod, colorimetric assay. Result: The mean level of serum copper was observed to be 521±376.7 μg/dl in MetS cases whereas the mean concentration was 232.9±138.25 μg/dl among the healthy subjects. An insignificant higher value of circulating Zn was observed among the MetS cases i.e. 131.54±92.7 μg/dl as compared to the healthy controls which was 116.55±62.81 μg/dl (p> 0.05). Serum Iron concentration when compared between the study groups, mean concentration of serum iron was found to be 243.76 ± 154.4 μg/dl in MetS subjects which was significantly higher than in the healthy controls with mean concentration 188.87 ± 129.2 μg/dl (p< 0.05). Conclusion: The MetS patients show higher values of Serum Copper, Zinc and Iron and are correlated significantly with few of the attributes of Metabolic Syndrome.