Adiponectin resistin ratio beneficial index of insulin sensitivity in women with PCOS

Abstract

Objective: Regular physical activity wheels important interactive pathways linking energy balance, neuroendocrine function and hypothalamic pituitary ovarian axis. Consistent physical activities are known to improve insulin sensitivity which exerts its effects via adipokines. Purpose of the study is to determine insulin resistant status and the effect of brisk walking on the levels of adipocytokines in women with Polycystic ovarian syndrome. Design: Prospective study was conducted in infertile women in reproductive age group of 21 to 40 years diagnosed as polycystic ovarian syndrome according to Rotterdam’s criteria with irregular menstrual cycle but anxious to conceive. Methods: Study included 143 PCOS married women (as per Rotterdam’s criteria) and 110 married women as control with atleast one child through natural conception. Anthropometric measurements were documented Adiponectin and Resistin were analyzed. HOMA-IR and HOMA-adiponectin was calculated to assess insulin resistance. Follow-up task of 150 mins/week of physical activity of brisk walking of moderate intensity was advised for 12 weeks and status reassessed. Results: Hypoadiponectinemia and hyperesistinemia with elevated markers of insulin resistance (HOMA-IR and HOMA-adiponectin) was observed in 143 PCOS infertile women. The baseline data were compared with estimates after 12 weeks, it was found that adiponectin levels were increased with 4.75% of weight loss and decreased Resistin, HOMA-IR and HOMA-adiponectin was observed. Participants who met 150 mins/week of brisk walking revealed an increase in adiponectin levels with strongly positive correlation (r = 0.76) was observed with regression analysis of METs/week physical activity with adiponectin levels. Diagnostic sensitivity and specificity of Adiponectin at a cut-off value of 7.3 μg/ml with 150 mins/week of physical activity was found to be 93.8% and 82.1% respectively. Conclusion: Brisk walking of 150 mins/week had resulted in 4.75 % of weight reduction as well as increased Adiponectin levels. Beneficial Adiponectin facilitates ovulatory menstrual cycle and thereby the chance of ovulation is increased in PCOS women.