FORMULATION AND CHARATERIZATION OF CURCUMIN PERIO DONTAL FILMS FOR LOCAL DELIVERY OF ANTIMICROBIALS

Abstract

A novel periodontal film for the treatment of periodontitis was developed in the present work, for local delivery of herbal drug Curcumin was used, which is affective against infecting microorganisms in the periodontal pocket. Calibration curves for Curcumin was developed in phosphate buffer PH 6.6, FT-IR investigations demonstrated that the chosen drug and polymers had no interaction. Thermal analysis technique accomplished for identification of various physical properties and thermal transitions of drug and the polymeric materials Periodontal films were prepared by solvent casting technique using Eutragit and HPMC as polymers, Dibutyl phthalate as plasticizers and PEG 800 as surface active agent. The formulated periodontal films were assed for folding endurance, percent moisture loss, surface pH, viscosity, thickness, uniformity of weight, content uniformity as well as in-vitro release To explain release kinetics, evidence of in-vitro delivery from constructed periodontal films was fitted into various equations and kinetic models. Zero first-order equations and Higuchi models were employed as kinetic models. By fitting the data to the Korsemeyer-Peppas model, the release mechanism was discovered. The optimal formulation (F 4) was placed in vivo to study in vivo drug release by placing Curcumin periodontal film(F 4) in rabbit’s gingival sulcus for 14 days and the drug release was analysed by HPLC method. The AUC peaks showed that the drug concentration was sufficient enough to inhibit the growth of bacteria.