Serum SARS-COVID-19 IgG Level Effect on Oocyte and Embryo Quality in Women Underwent ICSI

Abstract

Background: SARS-COVID-19 pandemic become a major health problem and impinge a large burden on health systems. SARS-CoV-2 utilize ACE2 receptors as a main port for its entry to the cells. These are widely spread in the body including ovaries. They are important for ovarian development. Therefore SARS-CoV-2 infection may have long term consequences of female’s fertility and on parameters that determine ART outcomes. This study designed to display if there is a long term effect of this disease on ova and embryo qualities during ART procedures.
Material and methods: This is a cohort study enrolling 54 infertile women attending our institute for ICSI procedure. Parameters determine
oocytes and embryo quality are recoded. Serum SARS-CoV-2 IgG measured and patient classified in those with negative (<1) and positive (≥1) groups.
Results: There are no significant differences between cases with negative and positive SARS-CoV-2 IgG in parameters for oocytes and embryo quality: p value for oocytes no. 0.84, abnormal oocytes 0.25, germinal vesicles 0.46, MI 0.52, MII 0.75, number of embryo transfer 0.86, G1 embryo 0.82, maturation rate 0.79, and fertilization rate 0.61.
Conclusion: There are no long term effect of SARS-CoV-2 infection on embryo and ova quality in patient have ART procedures.