Effect of Age on Serum and Follicular Fluid BMP15 and GDF9, The Oocyte Secreted Factors
DOI:
https://doi.org/10.47750/pnr.2022.13.04.055Keywords:
BMP15, GDF9, Folliculogenesis, Oocyte Quality, Oocyte Secreted Factors, IVF, ICSI.Abstract
Background: In female fertility, age is a most important factor. With increasing age, there will be decrease in both oocyte quantity and quality, and ovulatory dysfunction, is more common in younger female (1).
Aim of study: Evaluation of the effect of age on serum and follicular fluid BMP15 and GDF9, the oocyte secreted factors. Subjects, Materials and Methods: One hundred and seventy six women were included in this study, eighty eight women (Group 1) are selected from those undergoing intra-cytoplasmic sperm injection, also eighty eight postmenopausal women (group 2).
Results: Age was not significantly correlated to serum or follicular fluid BMP15 and serum and follicular GDF9 (p > 0.05) in premenopausal group, but decreased significantly with age in postmenopausal group.
Conclusions: Very low level of serum BMP15 in women could be used as indicator of empty follicles and menopause.
