Dynamic role of IL-33, ST2 axis, SOD, leptin and nitric oxide in pathogenicity and disease progression in HBV chronic infection in Iraqi patients

Authors

  • Hala Fouad Kasim AL-Eqabi
  • Sabah Abd AL- Hameid Abd AL- Rahman
  • Hazima Mossa ALabassi

DOI:

https://doi.org/10.47750/pnr.2022.13.04.031

Keywords:

HBV, Chronic hepatitis B infection, IL-33 ,IL-33R , Leptin , nitric oxide, SOD

Abstract

Chronic hepatitis B infection remains a major health problem worldwide. The objective of this study was to investigate the role of some
physiological and immunological aspect in the pathogenicity of HBV patients with chronic infection ,in addition to assess the correlation coefficient between the two aspect and the effect of each on the other and their impact on the progression of the disease. The study was conducted on two hundred blood sample were collected from each participants in this study, 150 Iraqi men patients with chronic hepatitis B with age average 25- 55 years, in addition to 50 blood sample for apparently healthy men individuals with the same average age was used as control group . The samples were collected during the period from January 2021to January 2022. And this study was done in the Hepatology and Gastroenterology Teaching hospital in Baghdad . All samples in present study were examined using the Polymerase Chain Reaction (PCR) technique to detect HBV DNA through the amplification of a pathogen's specific region of the genome using specific primers. And we selected the positive sample only then determine the IgM and IgG concentration to detect the chronic infection. Immunological parameters ,the result revealed a high significant elevation (P<0.01) in the mean value of IL-33 and IL-33R axis and their receptors for patients (236.60 ±14.41),(268.84 ±17.92) Pg/ml respectively (P≤0.01).when compared to control group,(161.46 ±14.54), (175.51 ±7.15) Pg/ml respectively. physiological parameters, the result showed a high significant increase (P<0.01) , the mean value of Leptin and nitric oxide levels for patients was (1.228 ±0.06) ng/ml(6.27±0.56) IU/ml respectively (P≤0.01).when compared to control group(0.919 ±0.06) ng/ml, ( 2.919±0.21) IU/ml respectively and a decrease in the level of SOD in patients (266. 62 ±9.45) Pg/ml when compared to control group (378.23 ±25.32) IU/ml. According to the present result, we can conclude that the under studied immunological parameters may consider a good therapeutic target to prevent the disease progression and we can consider physiological parameters a good marker for disease progression

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Published

2022-10-07

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Section

Articles

How to Cite

Dynamic role of IL-33, ST2 axis, SOD, leptin and nitric oxide in pathogenicity and disease progression in HBV chronic infection in Iraqi patients. (2022). Journal of Pharmaceutical Negative Results, 13(4), 258-263. https://doi.org/10.47750/pnr.2022.13.04.031