Anastrozole Nanoparticles for Transdermal Delivery through Microneedles: Preparation and Evaluation


  • Kamil K. Atiyah Altameemi
  • Shaimaa N. Abd-Alhammid



Anastrozole, Polymeric nanoparticles, Dissolving microneedles.


This study examined transdermal anastrozole (ANA) as an oral alternative. ANA is a nonsteroidal aromatase inhibitor licensed to treat breast cancer and metastatic disease. Estrogen makes breast cancer worse. However, ANA is only available as a once-daily oral tablet. In this work, dissolving microneedles that were loaded with ANA polymeric nanoparticles allowed for the transdermal distribution of anastrozole.
Method: ANA polymeric nanoparticles were created by the nanoprecipitation process utilizing the polymeric matrix kollicoat MAE100-55, and their physical characteristics and in-vitro release were investigated. Using different water-soluble polymers and the micro-molding method, four formulas of dissolving microneedles loaded with ANA polymeric nanoparticles were created. Additionally, the prepared needles' morphology, mechanical strength, moisture uptake percentage, and moisture loss percentage were examined.
Result: The ANA polymeric nanoparticles are 50.49±7.9nm in size, have a polydispersity index of 0.19±0.07, and have an entrapment efficiency of 75±4.5%. While employing poloxamer188 as a stabilizer, complete drug release took place in 3.5 hours. Among the various polymers used to make dissolving microneedle formulas, M-2 made from PVA demonstrated superior mechanical strength, moisture loss percentage, and moisture uptake. Ex vivo permeation through abdominal rat skin confirmed the penetration-enhancing impact of microneedles as permeation increased by 4.9 times compared to bare skin. Histology found no inflammatory reactions or cellular pathology with needle penetration.
Conclusion: It was possible to successfully manufacture polymeric nanoparticles of ANA and load them onto dissolving microneedles with sufficient mechanical strength to penetrate the stratum corneum and permit nanoparticle transdermal delivery.







How to Cite

Anastrozole Nanoparticles for Transdermal Delivery through Microneedles: Preparation and Evaluation. (2022). Journal of Pharmaceutical Negative Results, 13(3), 974-980.