A comprehensive review on potential pharmacological activities of Morinda citrifolia Linn. for the treatment of central nervous system disorders

Abstract

Back ground: In brazil, the plant Morinda citrifolia, popularly known as noni, is widely utilized in traditional medicine. Many components of the noni tree, including the roots, leaves, and seeds, are used in these traditions. Because of its high antioxidant activity and established health advantages Morinda citrifolia (Noni) has been widely utilized as a complementary and alternative medicine in many countries. The noni plant has an ancient legacy of being used to cure a range of diseases including CNS abnormalities. It has historically used as an antidepressant, anxiolytic, antiepileptic activity, antipsychotic, nootropic activity, anticraving activity aganist alcohol dependence, antiemetic activity, neuroprotective agent. Objective: Based on preclinical research published in the literature, the current study underlines noni therapeutic potential activities for the treatment of cns disorders.The literature was collected from research gate, Wikipedia, medline,scholarly articles, online databases and academic search.The present review targeted on mostly receptors,enzyme transporters and invivo, invitro and insilico methods for different cns disorders.Conclusion:The monoamine oxidase (MAO) A and B bioassays were used to evaluate the antidepressant effects of Morinda citrifolia (noni) fruit extracts invitro.Nonifruit has a synergistic impact because of its active components, involved in inhibiting MAOA and MAOB enzymes.The methanolic extract of noni shows antipsychotic activity by inhibiting dopaminergic receptors.Administration of benzodiazepine and MMC attenuated anxiolytic activityin mouse models.Noni inhibits acetycholine esterase enzyme and exhibits nootropic activity.Noni exhibits anticraving activity against alcoholdependence by CPP test.Noni exhibits neuroprotective activity by decreasing the brain damage and dysfunction caused by reperfusion injury.