HLA Typing And Donor Relation In Stem Cell Transplant Success: A Case Study Compilation

Abstract

Background: The development of stem cell transplantation has become a revolutionary therapy for many hematologic and immunologic diseases such as leukemia, lymphoma, and some genetic diseases.

Objective: The purpose of this study is to accumulate and compare the data of 84 patients, who underwent stem cell transplantation, regarding the connection between HLA matching, donor relation, and transplantation success.

Study Design: This study is a retrospective case compilation study.

Duration and Place of the study: This study was conducted at Gambat Institute  of Medical Sciences , with a specialized stem cell transplant unit, between 2^nd, September 2018 to 1^st, August 2019.

Material and Methods: Of all the 84 patients who underwent stem cell transplantation, concerning the patients involved in the study, they were suffering from hematologic and immunologic disorders such as leukemia, lymphoma, aplastic anemia, and inherited metabolic disorders. All patients were treated with conditioning regimens according to the patient’s state and the regimens were either myeloablative, and reduced-intensity conditioning.

Results: In the current study with 84 patients, the demographic data and pre-surgical clinical characteristics were compared according to donor kinship. The mean age of patients was 4.5 years, with the standard deviation of 1.2 years, and among patients with related donors, the mean age was 4.3 years and those recipients who had a donor unrelated to them had a mean age of 4.8 years.

Conclusion: In this paper, we discuss the details regarding the patients’ characteristics, HLA matching, graft survival, and complications of patients who underwent BMT from related and unrelated donors.