Preparation And In Vitro Characterisation OfMetformin Loaded Polymeric Nanoparticles ForGastroretention

Authors

  • Gamal Osman Elhassan , Jamal Moideen Muthu Mohamed , R.A.M. Jainaf Nachiya , Jiyauddin Khan

DOI:

https://doi.org/10.47750/zkhpr715

Abstract

The objective of current study was to formulate and assess metformin hydrochloride (MET) nanoparticles (NPs) utilising various hydrophilic polymers. To formulate nanoparticles without the side effects on the body of surfactants and chlorinated solvents, the nano precipitation approach was employed. MET-NPs were synthesised by hydrophilic polymers, including gelatin, chitosan, and HPMC K100M. Particle size (PS), polydispersity index (PDI), zeta potential (ZP), loading capacity (LC),
encapsulation efficiency (EE), and drug excipient compatibility were then assessed for the prepared formulations. Satisfactory results were obtained from the preparation of a nanoparticulate formulation using chitosan in a 1:1 ratio. The average PS was321.14 ± 11.20 nm, the PDI was 0.432 ± 0.04, the ZP was 29.4±3.14 mV, the LC was 19.11 ± 0.43 %, and the EE was 78.9 ± 1.22 %. The drug and the polymers utilised in this investigation did not interact significantly, according to the results of the
FTIR examination.

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Published

2023-12-15 — Updated on 2023-12-15

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Articles

How to Cite

Preparation And In Vitro Characterisation OfMetformin Loaded Polymeric Nanoparticles ForGastroretention. (2023). Journal of Pharmaceutical Negative Results, 141-146. https://doi.org/10.47750/zkhpr715