Results Of Node Positive Oral Cavity Cancer Patients Of North-East India Treated With Surgery Followed By Adjuvant Therapy: A Retrospective Study

Authors

  • Bhaskarjyoti Talukdar , Jhilam Gautam , Navin Nayan , Jibon Sharma

DOI:

https://doi.org/10.47750/

Abstract

OBJECTIVE: The objective of this study is to evaluate the pattern of failure and risk factors associated with the loco-regional or distant failure after surgery followed by adjuvant therapy in radically treated node positive oral cavity cancer patients of North-East India.  

MATERIAL AND METHODS: All node positive oral cavity cancer at diagnosis treated with surgery followed by adjuvant therapy in the period of 2017 to 2018 (2 years data) at State Cancer Institute (SCI), Gauhati Medical College (GMC), Assam were included in the study. Retrospective data were analyzed to assess the pattern of failure (loco-regional/distant) and risk factors associated with this failure. Survival outcomes were also analyzed.    

RESULTS: Total 39 node positive oral cavity cancer patients treated with surgery followed by adjuvant therapy. Median disease-free survival (DFS) was 27 months [Standard Error (S.E) =8.037, Confidence Interval (C.I) =11.247 – 42.753]. However, 20 (51.3%) patients developed local recurrence, 8 (20.5%) patients developed only neck node recurrence and 9 (23.1%) patients developed distant metastasis to lung. Only two patients remained disease free till the time of analysis.

CONCLUSION: The likelihood of recurrence is significant in locally advanced oral cavity cancer, particularly when nodes were positive at diagnosis. The median disease-free survival (DFS) in our study was just 27 months. More intensive treatment is necessary in order to increase the overall survival (OS) and DFS.

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Published

2022-09-15 — Updated on 2022-09-15

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How to Cite

Results Of Node Positive Oral Cavity Cancer Patients Of North-East India Treated With Surgery Followed By Adjuvant Therapy: A Retrospective Study. (2022). Journal of Pharmaceutical Negative Results, 13(3), 1131-1136. https://doi.org/10.47750/