Effect Of Donor And Red Blood Cells Concentrate Characteristics On Recipient Hemoglobin Increment Following Red Blood Cells Transfusion In Pediatric Patients
DOI:
https://doi.org/10.47750/Abstract
Introduction: Red blood cell (RBC) transfusion is a crucial and life-saving intervention for pediatric patients with anemia or other conditions that require rapid restoration of hemoglobin levels.
Objectives: The main objective of the study is to find the effect of donor and red blood cells concentrate characteristics on recipient hemoglobin increment following red blood cells transfusion in pediatric patients.
Material and methods: This retrospective observational study was conducted in one of the public hospitals of Karachi from 1st June 2022 till 1st June 2023. Demographic information, including age, sex, and weight, was recorded. Additionally, details about the primary diagnosis that led to the RBC transfusion was noted to account for differences in underlying medical conditions among the participants.
Results: Data was collected from 150 patients of both genders and the mean age was 8.5±3.2 years. The patients' primary diagnoses varied, with the most common indications for RBC transfusion being anemia due to chronic illnesses (45%), acute blood loss (30%), and surgical procedures (25%). The study found that the average pre-transfusion hemoglobin level among the participants was 8.0 g/dL (± 1.2 g/dL). After RBC transfusion, the post-transfusion hemoglobin level increased to an average of 9.2 g/dL (± 1.1 g/dL).
Conclusion: It is concluded that donor age and Rh blood group are essential determinants of Hb increment in recipients. Pediatric patients receiving blood from younger donors and Rh-positive donors showed significantly higher mean Hb increments compared to those from older donors and Rh-negative donors, respectively.
