Investigation Of Papaverine And Laudanosine As Alpha Amylase Inhibitors For The Treatment Of Diabetes Mellitus

Abstract

The present study was designed to specifically investigate the inhibitory effects of two naturally occurring compounds, Papaverine and Laudanosine, on alpha amylase activity. A comprehensive evaluation of the absorption, distribution, metabolism, excretion, and toxicity (ADMET) characteristics of the compounds was undertaken. Following the aforementioned procedures, a series of molecular docking investigations were conducted in order to assess the binding affinity capabilities of the aforementioned compounds towards the alpha amylase enzyme. From in silico ADMET analysis it was concluded that, these compounds possess drug-likeness properties. From molecular docking it can be concluded that Laudanosine is having very less binding affinity with alpha amylase and it is forming very less stable complex with it whereas, Papaverine significantly having very good binding affinity and forming more stable complex with alpha amylase. Papaverine can be developed further as potential alpha amylase inhibitor for the treatment of diabetes mellitus. Furthermore, it is imperative to generate a substantial amount of high-quality data through the utilization of a wider range of in vitro and in vivo models.