Effect Of Pterostilbene Compared To Tetrahydrocurcumin On Liver And Kidney Functional Markers And Protein Levels In Experimental Diabetes

Authors

  • MURUGAN P , SAKTHIVEL V

DOI:

https://doi.org/10.47750/pnr.2021.12.01.16

Abstract

Pterostilbene (PTS), a compound most abundantly found in blueberries, is a natural analog of resveratrol. Several plant species, such as peanuts and grapes, produce PTS. It has increased bioavailability in comparison to other stilbene compounds, which may enhance its dietary benefit and possibly contribute to a valuable clinical effect. PTS is a naturally-derived stilbenoid structurally related to resveratrol, with potential antioxidant, anti-inflammatory, pro-apoptotic, antineoplastic and cytoprotective activities. Upon administration, PTS exerts its anti-oxidant activity by scavenging reactive oxygen species (ROS), thereby preventing oxidative stress and ROS-induced cell damage. Tetrahydrocurcumin (THC) is one of the major metabolites of curcumin which exhibits many of the same physiologic and pharmacological activities as curcumin and in some systems may exert greater antioxidant activity than curcumin. Oral administration of PTS (40 mg/kg body weight) THC at 80 mg/kg body weight to diabetic rats for 45 days resulted in a significant reduction in blood glucose and significant increase in plasma insulin levels. In addition, the diabetic rats had decreased the levels of plasma total protein, albumin, globulin and albumin/globulin ratio as compared to control rats. After treatment with PTS and THC total protein, albumin, globulin and albumin/globulin ratio were brought back to near normal levels. The activities of hepatic and renal markers were significantly elevated in diabetic rats as compared to control rats, and treatment with PTS and THC have reversed these parameters to near normal levels. In diabetic rats, the decreased levels of urea, uric acid and creatinine with increased levels of was observed, and treatment with PTS and THC have reversed these parameters to near normal levels. THC had a better protective effect when compared with PTS.

Downloads

Published

2021-01-15 — Updated on 2021-01-15

Issue

Section

Articles

How to Cite

Effect Of Pterostilbene Compared To Tetrahydrocurcumin On Liver And Kidney Functional Markers And Protein Levels In Experimental Diabetes. (2021). Journal of Pharmaceutical Negative Results, 12(1), 103-109. https://doi.org/10.47750/pnr.2021.12.01.16