Formulation And Optimization Dispersible Tablets Using Of Solid Dispersions Of Poorly Water-Soluble Drug Etoricoxib

Authors

  • Manohar Chouhan, Dr. Mohit Chaturvedi , Dr. Raju Choukse, Dr.Monika kharb ,Dr. Rakesh Patel

DOI:

https://doi.org/10.47750/pnr.2021.12.01.13

Abstract

The aim of this research study was to formulate and optimize solid dispersions to improve the solubility of poorly soluble drugs. Solid dispersion, a technique involving the dispersion of such drugs in a solid matrix, was employed using various water-soluble carriers, including poloxamer 188, poloxamer 407, PEG 4000, and PEG 6000, in different ratios. The prepared solid dispersions were evaluated for physical appearance, drug lodging, solubility, and drug release. Among the different formulations, the F11 formulation demonstrated optimized results. Subsequently, the F11 formulation of the solid dispersion was utilized in the preparation of dispersible tablets. Super disintegrating agents, namely Crospovidone and SSG (sodium starch glycolate), were incorporated in different ratios (10, 15, and 20). The dispersible tablets were formulated using the direct compression method. Comprehensive precompression and post-compression evaluations were performed to ensure the quality and optimization of the tablets. Upon completion of the evaluation process, it was observed that the F2 formulation displayed the most favorable outcomes among the dispersible tablet formulations. Consequently, the conclusion was drawn that the F2 formulation of the dispersible tablet, containing the optimized solid dispersion, exhibited improved solubility, drug release, and overall performance. These findings highlight the potential of solid dispersions and dispersible tablets as effective strategies for enhancing the bioavailability and formulation properties of poorly soluble drugs.

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Published

2021-01-01 — Updated on 2021-01-01

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Articles

How to Cite

Formulation And Optimization Dispersible Tablets Using Of Solid Dispersions Of Poorly Water-Soluble Drug Etoricoxib. (2021). Journal of Pharmaceutical Negative Results, 12(1), 80-92. https://doi.org/10.47750/pnr.2021.12.01.13