The Efficacy Of Nutritional Supplementation In The Therapy Of Metabolic Dysfunctions Associated With Polycystic Ovarian Syndrome: A Critical Review

Abstract

PCOS is a complicated heterogeneous condition with multiple pathological manifestations, including metabolic, endocrine, reproductive, and psychological. However, the aetiology of PCOS is yet unknown. Numerous studies indicate that insulin resistance and hyperandrogenism are critical factors in the pathogenesis of PCOS. As a result, the majority of PCOS treatment techniques focus on lifestyle improvement, including exercise, nutrition, and nutrient supplementation therapy. Recent studies have indicated some nutrients for the treatment of PCOS, including vitamins, minerals, and vitamin-like substances, because each has at least one functional feature in PCOS-induced pathways. As a result, vitamin or mineral deficiency is suggested as a possible cause of PCOS. The purpose of this review is to conduct a comprehensive literature search on nutritional supplements for the treatment of PCOS-related endocrine and metabolic dysfunctions and to examine the role of nutrients in PCOS management in light of clinical trials and experimental investigations. (Turkish Journal of Gynecology and Obstetrics 2018; 19: 220-32).