Anti-Bacterial And Anti-Fungal Activity Of Wild Plant Trillium Undulatum Against Multi-Drug Resistant Pathogens

Abstract

Finding novel medications to combat the threat of drug-resistant strains is crucial to the effectiveness of chemotherapy. T. undulatum extracts were tested for their antibacterial and antifungal efficacy, and the presences of phytochemicals responsible for its biological activity were identified. Secondary metabolites such phenols, terpenoids, quinones, cardiac glycosides, and alkaloids were found by phytochemical study. Using antibiotics as a standard, the well diffusion test was used to determine whether or not plant composites have antibacterial activity against a number of pathogens known to cause severe urinary tract infections. T. Undulatum was tested for its antibacterial properties against a variety of bacteria, including Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Salmonella typhi, using both ethanolic and aqueous extracts. Different plant extracts shown varied antibacterial activity. Aqueous plant extracts were more effective than ethanolic ones as antibacterial agents against gram-positive and gram-negative bacteria. The aqueous extracts of T. Undulatum showed the greatest antibacterial potential, inhibiting 26 mm of S. typhi, whereas the ethanolic extract showed 25 mm of inhibition. Several strains of fungi were killed by the plant, demonstrating its potent anti-fungal properties. When tested against the fungal strain Mycosphaerella citri, the aqueous and ethanolic extracts showed the highest zone of inhibition to be 17 mm. The findings provide credence to the traditional use of extracts from these plants as medicine.