Efficacy Of Commercially Available 10 Mg Curcumin Gel On Gingival Crevicular Fluid Periostin levels In In Chronic Periodontitis Patients

Abstract

Inconsistency of the host in immunoinflammatory processes in the gingival and periodontal tissues in response to bacteria is thought to be the cause of periodontal disease pathogenesis.¹The most common type of periodontitis is chronic periodontitis, which is characterized by a slowly growing inflammatory condition.²

In order to alleviate periodontal inflammation, a variety of treatment options such as nonsurgical and surgical therapy are available, depending on the severity of the disease.³ The reduction or removal of periodontal pathogens, whether by nonsurgical or surgical therapy, as well as the patient's systemic status, patient compliance, and other factors, determine the success of periodontal therapy. Scaling and root planing (SRP) is the first nonsurgical procedure that has been compared to other therapies in terms of removing plaque and calculus supragingivally as well as subgingivally and thereby returning tissues to a healthy state.⁴ Antibiotics, both local and systemic, can be administered in conjunction with SRP to treat chronic periodontitis. Because of its site specific nature and less adverse effects than antibiotics given systemically, chemotherapeutic drugs delivered locally through a syringe or irrigating devices into the pockets were effective against the flora located subgingivally.^3,5

Despite of the progress in medical science, plants are still considered to be an important source of drugs worldwide & there is renewed interest coming in for use of various ayurvedic medicines & herbal products for dental health.³“Turmeric (common name for curcuma longa) is yellow, water insoluble pigment, an Indian spice derived from the rhizomes, a perennial member of the Zingiberaceae family”.Curcumin (diferuloylmethane), bisdemothoxycurcumin, and demothoxycurcumin are active ingredients of turmeric, as with numerous volatile oils such as atlantone, turmerone, and zingiberone, as well as proteins, carbohydrates, and resins. Curcumin has anti-inflammatory, antioxidant, antibacterial, antiviral, anticarcinogenic, and anticarcinogenic properties.⁵