Evaluation Of The Relation Between Fetuin-A Protein And Adipocytokine Levels, Insulin Resistance In Iraqi Over-Weight Women With Polycystic Ovary Syndrome

Abstract

Polycystic ovary syndrome (PCOS) is a heterogeneous disorder and its etiology appears to be complex and multifactorial. It is one of the most frequent endocrine diseases, affecting about 5-12% of reproductive women. This study was designed to determine serum Fetuin-A levels and establish whether serum Fetuin-A level is related with insulin resistance, ovarian hyperandrogenism and dyslipidemia in women with polycystic ovary syndrome (PCOS). In addition to the selected one hundred PCOS patients with mean age of (29.01 ± 0.63years), and the mean body mass index (BMI) (28.29±0.99 Kg/m²). A group of seventy-five healthy women without PCOS matching in the mean age and BMI to the PCOS women (28.57±0.81 years, 29.68±1.06 Kg/m²) respectively were also recruited in the study as a control group.

Serum Fetuin-A, lipid fractions, glucose, insulin, and other hormone (gonadotropins, androgens) levels measurement conducted, Then estimate of insulin resistance calculated by homeostasis model assessment (HOMA-IR). The women with PCOS has significantly higher Insulin Serum, Luteinizing hormone (LH), Fetuin-A levels, and LH/FSH (Follicle-Stimulating hormone) ratio, Free Androgen Index (FAI), HOMA-IR, Interleukin 6, Interleukin 10, TNF-α, Leptin and hs-CRP, than healthy women(p<0.05). However, Sex Hormone-Binding Globulin (SHBG), Adiponectin and HDL-ch levels were significantly lower in patients with PCOS compared with controls. Fetuin-A was positively correlated with insulin, HOMA-IR and FAI (p< 0.05).

Serum Fetuin-A level related with insulin resistance and ovarian hyperandrogenism in women with PCOS. These results suggest that Fetuin-A may have a role in triggering the processes leading to insulin resistance and androgen excess in PCOS.