Mucoadhesive Tablets of Atenolol: Design, Formulation by using Thiomer Matrix and In- Vitro Evaluation

Abstract

The major goal of this study was to develop and evaluate gastric retentive mucoadhesive tablets of atenolol and synthesized a xyloglucan- or thiomer of tamarind seed polysaccharide-were used. The oral sustained release formulations with low risk of dosage clearance are particularly well suited for the mucoadhesive drug delivery systems. Amounts of synthesised and oxidised Xyloglucan-Cysteine conjugates (Thiomer), HPMC K100M, PVP K 30, Mg-Stearate, talc, and lactose were used to create the seven formulations F1 to F7, which were used to create mucoadhesive tablets using the direct compression technique. Weight variation, friability, hardness, thickness, drug content, swelling index, drug release profiles, and mucoadhesion studies were all assessed for the produced tablets. Characterization was carried out. The formulation (F3) shown highest drug release i.e., 94% because of highest percentage of lactose and F2 shown highest mucoadhesive force comparatively. It was observed that Thiomer tablet remains in stomach for 7h, while Xyloglucan tablet disappears within 3h. The developed tablets shown drug release time T50 between 4.5-9hrs, had release after 12hrs between 42-94%, had Mucoadhesive force between 6.8-18.4g and sustained the drug release beyond 12h. The bioavailability of Atenolol was seen to have increased by use of Thiomer. The use of drug delivery carrier can be further explored for increasing bioavailability of limited permeability drugs.