Phytochemical And Pharmacological Screening Of Isolated Compound Of Dolichandrone Falcate Leaves For Anti Inflammatory Activity

Abstract

Inflammation usually occurs when infectious microorganisms such as bacteria, viruses or fungi invade the body, reside in particular tissues and/or circulate in the blood. Inflammation may also happen in response to processes such as tissue injury, cell death, cancer, ischemia and degeneration. Mostly, both the innate immune response as well as the adaptive immune response is involved in the formation of inflammation. The objective of the present study was to evaluate the anti-inflammatory activity by carrageenan-induced paw animal models of ethanol extract of Dolichandrone falcata leaves and isolated compound from extract. Carrageenan-induced acute inflammation is one of the most suitable test procedures to screen anti-inflammatory agents. The time course of edema development in carrageenan-induced paw edema model in rats is generally represented by a biphasic curve. Formalin-induced paw edema is one of the most suitable test procedures to evaluate chronic anti-inflammation, as it closely resembles human arthritis.