Evaluation Of Anti-Cancer Potential Of Biosynthesized Silver Nanoparticles From Artabotrys Hexapetalus L.

Authors

  • Sushama Sahu , Ashish Saraf , Bhagyashree Deshpande , Suresh Kumar Subbiah

DOI:

https://doi.org/10.47750/pnr.2022.13.S10.581

Abstract

The biosynthesis of Silver nanoparticles (AgNPs) using Artabotrys hexapetalusL. leaf extract and its cytotoxicity potential has been carried out in this present investigation. The cytotoxicity of the synthesized As-AgNPs was evaluated against HCT 116colon cell lines, and the AgNPs were found to beeffective in inhibiting the multiplication of cancer cells. The cytotoxicity investigation revealed a dose-dependent inhibitory concentration (IC50) of 23.71 µg/ml against HCT116 cells. Furthermore, AgNO3efficiently suppressed proliferation, colony formation, and ROS generation when compared to untreated cells. Mechanistic research demonstrated that AgNO3 NPs stopped the cell cycle, decreased the expression of anti-apoptotic, inflammatory, and stem cell markers, and increased the expression of apoptotic genes in HCT116 cells. Finally, we describe for the green production of AgNO3 NPs utilizing Artabotrys hexapetalus leaf extract, which has potential anticancer efficacy.

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Published

2022-12-31 — Updated on 2022-12-31

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How to Cite

Evaluation Of Anti-Cancer Potential Of Biosynthesized Silver Nanoparticles From Artabotrys Hexapetalus L. (2022). Journal of Pharmaceutical Negative Results, 4799-4808. https://doi.org/10.47750/pnr.2022.13.S10.581