An Recent Advantage On Gastroretentive Drug Delivery System: An Overview

Abstract

The gastro-retentive drug delivery system (GRDDS) has attracted the attention of researchers in the area of oral medication delivery in recent years. To keep the dose forms in the stomach and release the medication slowly over an extended period of time, many GRDDS techniques can be used. GRDDS can be utilised to extend the delivery system's duration in the stomach. As a result, the medicine is released specifically at that location for either local or systemic effects. In order to optimise the bioavailability of a certain therapeutic substance, GRDDS can be utilised to get around problems with traditional oral dosage forms and release the medication at a particular absorption site. Fast stomach emptying of the dose form, which causes poor drug bioavailability, is one of the difficulties. The solubility of medications is improved by keeping them in the stomach for a longer period of time when the intestinal pH is high. GRDDS has shown to be useful in treating gastric or duodenal ulcers both locally and systemically. By increasing the residence duration of the delivery system in the stomach, local action in the upper section of the small intestine can be attained. Drugs with low solubility or permeability in the small intestine or those that are unstable in the intestine can benefit from the system. High density (sinking) systems, low density (floating) systems, muco-adhesive, expandable, unfoldable, ultra porous hydrogel systems, and magnetic systems are some of the several GRDDS techniques.